Oncolytic virotherapy: basic principles, recent advances and future ...
WEBApr 11, 2023 · Oncolytic virotherapy is an emerging novel tumor therapeutic approach that selectively replicates in and destroys tumor cells while leaving normal cells undamaged. 1,2 Initially, in the...
Oncolytic Virus Therapy | Cancer Research Institute
WEBOncolytic virus therapy uses modified viruses that infect and destroy tumor cells. Learn more about how it's helping to advance cancer treatment.
Using Oncolytic Viruses to Treat Cancer - NCI
WEBFeb 9, 2018 · Cancer treatments known as oncolytic viruses are being tested in clinical trials, and one, T-VEC or Imlygic®, has been approved by the FDA. Research now suggests that these treatments work not only by infecting and killing tumor cells, but that they may also be a form of cancer immunotherapy.
Oncolytic virus therapy in cancer: A current review - PMC
WEBSep 9, 2021 · In this manuscript, we will present a current review of the mechanism of action of OVs, main clinical uses, updates, and future perspectives on this treatment. Keywords: Oncolytic viruses, Antitumor response, …
Therapy with oncolytic viruses: progress and challenges
WEBJan 11, 2023 · Oncolytic viruses (OVs) are a promising emerging class of anticancer immunotherapies that exploit the innate ability of certain replication-competent viruses to infect and preferentially lyse...
Oncolytic Viruses: Newest Frontier for Cancer Immunotherapy
WEBOct 29, 2021 · Oncolytic viruses (OVs) are viruses that selectively target and kill cancer cells while sparing normal ones. OVs are from diverse families of viruses, but naturally occurring OVs have been genetically engineered due to …
Optimizing oncolytic virotherapy in cancer treatment - Nature
WEBJul 10, 2019 · In the wake of the success of modern immunotherapy, oncolytic viruses (OVs) are currently seen as a potential therapeutic option for patients with cancer who do not respond or fail to achieve...
Oncolytic Viruses for Cancer Therapy: Barriers and Recent Advances
WEBDec 12, 2019 · Oncolytic viruses (OVs) are powerful new therapeutic agents in cancer therapy. With the first OV (talimogene laherparepvec [T-vec]) obtaining US Food and Drug Administration approval, interest in OVs has been boosted greatly. Nevertheless, despite extensive research, oncolytic virotherapy has shown limited efficacy against solid tumors.
Mayo Clinic researchers load CAR-T cells with oncolytic virus to …
WEBMay 11, 2022 · Oncolytic viruses are naturally occurring viruses that can infect and break down cancer cells. They either naturally replicate well in cancer cells or can be engineered to selectively target cancer cells. The study suggests CAR-T cells can deliver the oncolytic virus to the tumor.
Oncolytic Virus Therapy: How Does it Work, Benefits & Risks
WEBSep 12, 2023 · A group of viruses known as oncolytic viruses (OVs) are being used to treat cancer, particularly advanced metastatic melanoma. The first oncolytic virus therapy approved by the U.S. Food and Drug Administration for the treatment of melanoma is Imlygic ® (talimogene laherparepvec, or T-VEC).