The Grampians is an economic rural region located in the western part of Victoria, Australia. The 48,646-square-kilometre region lies to the northwest of the western suburbs of Greater Melbourne, to the state's western border with South Australia and includes the Grampians National Park and significant gold mining heritage assets. The Grampians regiā¦The Grampians is an economic rural region located in the western part of Victoria, Australia. The 48,646-square-kilometre region lies to the northwest of the western suburbs of Greater Melbourne, to the state's western border with South Australia and includes the Grampians National Park and significant gold mining heritage assets. The Grampians region has two sub-regions: the Central Highlands and Wimmera Southern Mallee.