Creighton is a city in Knox County, Nebraska, United States. The population was 1,154 at the 2010 census. The City of Creighton deve…Creighton is a city in Knox County, Nebraska, United States. The population was 1,154 at the 2010 census. The City of Creighton developed as a result of the “Bruce Colony” settlement in 1871. A charter was obtained in 1874 to plat the north side of what is now the mile-long Main Street. Some say the town was named for Edward Creighton, while others claim it was for John, for whom Creighton University was named.