The 49ers announced that DL Evan Anderson and S Jaylen Mahoney have been activated from the team's practice squad ahead of "Thursday Night Football." The San Francisco 49ers ...

Left tackle Trent Williams (toe) and safety Talanoa Hufanga (ankle) were surprise additions to the 49ers’ injury report Friday, as each missed practice. Both are questionable for Sunday’s game ...

SANTA CLARA -- Even after all the success the San Francisco 49ers had the past few seasons, a two-game skid and a string of injuries early in the season can raise some doubts for any team.

Apparently, Brandon Aiyuk's $120 million extension isn't enough to keep him happy. The 49ers wide receiver, who has woefully underperformed through the season's first three weeks, let his ...

Deebo Samuel missed most of the 49ers' 28-18 loss to the Kansas City Chiefs with an illness that technically is pneumonia according to head coach Kyle Shanahan. Which means Samuel has fluid in his ...

Things are even more bleak for San Francisco 49ers star running back Christian McCaffrey. Head coach Kyle Shanahan confirmed that McCaffrey is dealing with Achilles tendinitis in both of his legs ...

The San Francisco 49ers departed their win against the New ... He was seen on the sideline in a helmet and testing the ankle to open the third quarter but did not return. After the game, Warner ...

The Dallas Cowboys will be coming off their bye week the healthiest they’ve been since Week 4; however, the San Francisco 49ers will come in just as desperate as the Cowboys. Dallas has been ...

The 49ers piled up 431 yards of offense and two touchdowns, their defense collected three turnovers — including Fred Warner’s 45-yard interception returned for a touchdown in the second ...

The 49ers are trying to stave off the dreaded Super Bowl hangover and have gotten off to a 1-2 start, and now video has emerged of head coach Kyle Shanahan confronting star wideout Brandon Aiyuk ...

Deebo Samuel was projected miss multiple weeks with a calf injury that forced him out of the San Francisco 49ers game in Week 3 against the Los Angeles Rams. But now, it’s looking like a ...