The researchers looked particularly at CBASS-associated protein 5 (Cap5) in Pseudomonas bacteria. Cap5 is activated by cyclic nucleotides, small signaling molecules or ‘second messengers’ that ...

New approach to tackling bacterial infections identified Researchers unveil how the self-killing activity of bacteria can be harnessed in the fight against antibiotic resistance Date: February 6, 2024 ...

Researchers at the Icahn School of Medicine at Mount Sinai have identified a new approach to controlling bacterial infections. The findings were described in the February 6 online issue of Nature ...

Cap5 is a key protein that becomes activated by cyclic nucleotides (small signaling molecules) to destroy the bacterial cell's own DNA. ... Antibiotic Resistance, Bacteria, Cardiology, Cell, ...

The team found a way to turn on a vital bacterial defense mechanism to fight and manage bacterial infections. The defense system, called cyclic oligonucleotide-based antiphage signaling system ...

In 2023, the World Health Organization launched the Antimicrobial Resistance Diagnostic Initiative and called on researchers ...

William Bishai and colleagues report that cyclic-di-adenosine monophosphate produced during infection with Mycobacterium tuberculosis induces IFN-β and contributes to the innate sensing of ...

Bacterial CDNs also elicit immune responses during infection when they are detected by pattern-recognition receptors in animal cells. Here we perform a systematic biochemical screen for bacterial ...

BUFFALO, N.Y. – To combat “hypermutated” strains of deadly, antibiotic-resistant bacteria, the National Institute of Allergy and Infectious Diseases has awarded the University at Buffalo a $4 million ...

Bacteria self-destruct as a means to prevent the ... can be used in the fight against antibiotic resistance. ... of the many cyclic nucleotides could activate the effector Cap5 of ...