The researchers looked particularly at CBASS-associated protein 5 (Cap5) in Pseudomonas bacteria. Cap5 is activated by cyclic nucleotides, small signaling molecules or ‘second messengers’ that ...

Researchers at the Icahn School of Medicine at Mount Sinai have identified a new approach to controlling bacterial infections. The findings were described in the February 6 online issue of Nature ...

New approach to tackling bacterial infections identified Researchers unveil how the self-killing activity of bacteria can be harnessed in the fight against antibiotic resistance Date: February 6, 2024 ...

Cap5 is a key protein that becomes activated by cyclic nucleotides (small signaling molecules) to destroy the bacterial cell's own DNA. ... Antibiotic Resistance, Bacteria, Cardiology, Cell, ...

The team found a way to turn on a vital bacterial defense mechanism to fight and manage bacterial infections. The defense system, called cyclic oligonucleotide-based antiphage signaling system ...

Indeed, no single type of phage investigated by Hobbs et al. could degrade all known cyclic nucleotides involved in bacterial defence, despite the broad substrate specificities of the phage nucleases.

In 2023, the World Health Organization launched the Antimicrobial Resistance Diagnostic Initiative and called on researchers ...

Bacterial CDNs also elicit immune responses during infection when they are detected by pattern-recognition receptors in animal cells. Here we perform a systematic biochemical screen for bacterial ...

BUFFALO, N.Y. – To combat “hypermutated” strains of deadly, antibiotic-resistant bacteria, the National Institute of Allergy and Infectious Diseases has awarded the University at Buffalo a $4 million ...

Bacteria self-destruct as a means to prevent the ... can be used in the fight against antibiotic resistance. ... of the many cyclic nucleotides could activate the effector Cap5 of ...