Mice with macrophage-specific deletion of the major PGE 2 receptor, EP 4, also developed salt-sensitive hypertension, with aberrant macrophage polarization and increased NCC activity.

(HealthDay)—Macrophage cyclooxygenase-2 (COX-2) deletion is associated with progression of diabetic nephropathy (DN), according to an experimental study published online Nov. 4 issue of Diabetes.

Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, was used to inhibit prostaglandin E2 (PGE2) expression in these cells. ... (RT-qPCR) was performed to assess macrophage polarization.

In a study in mice, the Vanderbilt researchers found that when the COX-2 enzyme in macrophages was blocked, and thus prevented from making prostaglandins, hypertension and edema got worse.

Moreover, CS concomitantly promoted transition of M1 macrophages to M2 macrophages with increased oxidative phosphorylation, thus indicating that macrophage polarization may also be a potential ...