We developed an ex vivo co-culture system to interrogate pharmacologic or genetic perturbations that modulate anti-cancer immunotoxicity in CRC. Methods: Our system uses expanded CD8+ TILs & ...

The -SG diet inhibited the growth of CRC cells in culture. The anti-proliferative effect was coupled with a delay in entering the synthetic phase of the cell cycle.

However, miR-192/215-mediated TYMS downregulation did not translate into an increased sensitivity of CRC cell lines to 5-FU treatment. On the contrary, transfection with pre-miR-192 for 96 hours ...

Distant metastasis and drug resistance are the main causes of colorectal cancer (CRC)-derived mortality. Identifying the underlying mechanisms driving metastasis is key for improving its therapy.

A cell-free DNA (cfDNA) blood test, aimed at detecting abnormal DNA signals in people with an average risk of colorectal cancer (CRC), correctly detected CRC in most people confirmed to have the ...