Gene variation in immune system cells lowers heart disease risk ... In this population of more than 1,800 individuals, the researchers showed that a genetic variant of the CX3CR1 receptor, ...

Finally, the investigators evaluated 503 patients with Crohn’s disease, and found that those who carried a homozygous mutation in the CX3CR1 gene showed a reduced immune response to intestinal ...

The study (“CX3CR1 + Mononuclear Phagocytes Control Immunity to Intestinal Fungi”), published in Science, shows a strong connection between fungi, immunity, and intestinal inflammation and ...

Rare genetic variants in CX3CR1 and their contribution to the increased risk of schizophrenia and autism spectrum disorders. Translational Psychiatry , 2017; 7 (8): e1184 DOI: 10.1038/tp.2017.173 ...

Patients with only this CX3CR1-I249 allele had a substantially longer mean survival (23.5 v 14.1 months; P < .0001). The CCL2-2518G allele was not associated with patient survival. Immunohistochemical ...

In the new study, Dr. Iliev and his colleagues largely answered that question by identifying a type of white blood cell, the CX3CR1+ mononuclear phagocyte, as the immune system's major gut fungal ...

image: This is opportunistic fungus called candida albicans (red) engulfed by CX3CR1+ phagocytes (green) in the gut villi (blue). view more Credit: Dr. Iliyan Iliev and Dr. Irina Leonardi ...

The CX3CR1 blockade also decreased the number of infiltrating F4/80-positive macrophages in damaged kidneys. ... Gene therapy via blockade of monocyte chemoattractant protein-1 for renal fibrosis.

Chiome Bioscience Inc. and Asahi Kasei Pharma Corp. have entered into an exclusive license agreement to develop and commercialize Chiome’s humanized anti-CX3CR1 antibody, PFKR, currently in the ...

Polymorphism in the Microglial Cell-Mobilizing CX3CR1 Gene Is Associated With Survival in Patients With Glioblastoma The clinical records and pathology reports from women who underwent hysterectomy at ...

Rare genetic variants in CX3CR1 and their contribution to the increased risk of schizophrenia and autism spectrum disorders. Translational Psychiatry , 2017; 7 (8): e1184 DOI: 10.1038/tp.2017.173 ...