During S phase, any problems with DNA replication trigger a ‘' checkpoint" — a cascade of signaling events that puts the phase on hold until the problem is resolved.

This study reveals how SV40 helicase unwinds DNA, highlighting ATP hydrolysis's role in translocation and offering insights ...

But if you have a p53 mutation and you have dysregulated the G1-S cell cycle checkpoint, the cell is more likely to progress into S-phase with unrepaired DNA damage and have higher replication stress.

During an unperturbed S phase, DNA synthesis is catalyzed by the assembly of the multisubunit replisome at the replication fork (RF) to promote leading- and lagging-strand synthesis.

DNA replication occurs in the S phase of the cell cycle. DNA replication is the process where DNA copies itself. This happens so that old cells can make new cells.

Glucose levels influence physiology and adaptation rates under replication stress, yet core adaptive mutations remain ...

With support from the Ulrich lab, they found that yeast expressing RNase H2 exclusively during G2 (the 'growth phase' of the cell cycle following DNA replication) were resistant to MMS, whereas ...

DNA repair can occur at various points in the cell cycle, as outlined below: G1 phase: prevents the replication of errors by halting in this phase ...

Scientists have discovered that a protein known as Cdt1, which is required for DNA replication, also plays an important role in a later step of the cell cycle, mitosis. The finding presents a ...

DNA replication in early embryos differs from previous assumptions, study shows Aug 28, 2024 Researchers study nearly 1,000 fertility attempts hoping to improve IVF ...

Applied DNA Sciences (APDN) announced that the State Institute for Drug Control of the Czech Republic approved an application for a Phase I clinical trial of an investigational CD123-specific ...

The proteins that drive DNA replication—the force behind cellular growth and reproduction—are some of the most complex machines on Earth. The multistep replication process involves hundreds of ...