Single-strand changes in DNA occur continually as cells divide and multiply, and while layers of repair mechanisms fix most changes, some get through and become mutations.

A new long-read sequencing technique has helped researchers investigate how DNA mutations arise in a variety of contexts. A collaboration of researchers led by NYU Langone Health and NYU Grossman ...

However, researchers say, most mutations have their origins in DNA changes that are present in only one of the two DNA strands, and these single-strand changes, such as a mismatched G and T base ...

Strand-resolved mutagenicity of DNA damage and repair. Nature, 2024; ... Scientists demonstrate that DNA mutation itself may represent only a fraction the health-related ...

Insights into the persistence of DNA damage show how strand-specific interactions shape the genome-wide distribution of mutations, including the unexpected symmetry of mutations arising in the DNA ...

Your DNA is continually damaged by sources both inside and outside your body. One especially severe form of damage called a ...

After DNA damage, for example by chemicals, the damaged and undamaged DNA strands are separated from each other during cell division. The cells often do not repair the DNA damage immediately; the ...

Alphabet Inc.’s Google DeepMind today introduced AlphaGenome, a new artificial intelligence tool that can comprehensively ...

Although base editors do not induce double-strand breaks, they still nick the DNA and trigger a DNA repair response. Because of this, the researchers first examined if CBEs and ABEs would work on ...

More information: Xinzhe Tang et al, In vitro reconstitution of meiotic DNA double-strand-break formation, Nature (2025). DOI ...