(a) Tissue volumes with dimensions too large for FIB-SEM, such as an entire adult Drosophila brain, can be sectioned into optimally sized 'ultrathick' chunks and imaged across multiple FIB-SEM ...

A JPEG compressed image of a large brain slide tissue section at 20x resolution will be at least 100 GB, which is 10‑100 times larger than comparable images of a standard slide.

When the macrophages’ ability to consume dying cancer cells or Upd3 production was decreased, tumor growth was significantly ...

Serial section electron microscopy volume revealing the Drosophila brain structure. Image Credits: Michael Winding. The result is the model you see, ...

K nowing the location of a gene within intact tissue or a single cell allows scientists to unlock unknown cellular functions. This information is often lost in most genetic sequencing techniques, but ...

A tiny brain for immense discoveries. The fruit fly, this simple vinegar fly, holds within it the secrets of neural connections. Could understanding its brain pave the way for insights into human ...

The following article is the first of a three-part series on imaging large whole mount brain sections for neuroscience research. The series covers sectioning/staining, scanning, and data ...

Given the ongoing work in mouse and human tissue and further technological improvements, it is only a matter of time before similar networks will be derived for human brain cells as well.

Previous researchers mapped the brain of a C. elegans worm, with its 302 neurons, and the brain of a larval fruit fly, which had 3,000 neurons, but the adult fruit fly is several orders of ...

During Drosophila development, LECs slowly begin to undergo apoptosis. In the late phase, the LECs are rapidly eliminated, with full replacement by the histoblasts.

Researchers have developed CRISPR-LICHT, a revolutionary technology that allows genetic screens in human tissues such as brain organoids. By applying the novel technology to brain organoids, the ...

During embryonic development, groups of cells reorganize into functional tissues with complex form and structure. Tissue reorganization can be rapid and dramatic, often occurring through striking ...