Scientists have found a novel way that includes a new lab-grown material that could help slow and even reverse some of the ...

Collagens are the primary components of ECM in fibrosis. Other ECM components, including laminin, hyaluron, elastin and fibronectin are also increased during fibrogenesis.

Excessive ECM production is involved in conditions such as fibrosis, the development of damaging scar tissue in organs. Transforming growth factor β1 (TGF-β1) is a key signaling molecule within ...

Accordingly, fibrosis of the liver is now characterized (i) by an up to 10-fold increase of ECM that comprises several types of collagens, structural glycoproteins, sulfated proteoglycans ...

Insulin resistance is closely linked to ECM remodeling in peripheral tissues, where fibrosis (excess ECM deposition) impairs insulin signaling and action. Conventionally, fibrosis was believed to ...

Understanding the molecular mechanisms driving extracellular matrix (ECM) remodeling in PDAC fibrosis is crucial for overcoming treatment barriers. By dissecting these signaling pathways, ...

Chronic kidney disease (CKD) is typically associated with severe fibrosis, the exact pathogenesis of which remains unclear.

In contrast, young cells placed on "aged" ECM began to show signs of dysfunction, even if the scaffold was soft. "This showed us that the biochemical environment around aged heart cells matters ...

A new priority research paper was published on the cover of Aging's Volume 15, Issue 20, entitled, “Proteomic quantification of native and ECM-enriched mouse ovaries reveals an age-dependent ...

Although fibrosis is an important function and helps repair heart tissue after damage, when it is uncontrolled, it leads to a stiffer, less flexible ECM. In the case of the heart, this can make it ...