Spatial Characteristics of the Efflux Pump MexB Determine Inhibitor Binding. Antimicrobial Agents and Chemotherapy , 2022; DOI: 10.1128/aac.00672-22 Cite This Page : ...

Efflux pump proteins are present in many human cells and often share structural similarities, so further research will need to investigate how specific this novel inhibitor is in targeting cancer ...

More information: Jennifer C. Earp et al, Structural basis of siderophore export and drug efflux by Mycobacterium tuberculosis, Nature Communications (2025). DOI: 10.1038/s41467-025-56888-6 ...

Chemists have synthesized a new compound that makes drug-resistant bacteria susceptible again to antibiotics. The compound -- BU-005 -- blocks pumps that a bacterium employs to expel an ...

Nature Reviews Microbiology - This studies shows that in addition to passive dormancy, bacterial persisters use active efflux to pump antibiotics out of the cell to survive.

This bacterium has four efflux pumps involved in antibiotic resistance, and Turner predicted that if he could find a phage that used one of the pumps as a way into the cell, the bacterium would be ...

Different types of efflux pump proteins might have evolved independently, instead of divergently as previously thought. This could yield insights in mediating antibiotic resistance.

The efflux pumps had, in effect, given the microbes the exact loophole they needed to resolve the protein synthesis paradox. The pumps weren’t enough to confer drug resistance on their own ...

Efflux Pump’s Shape Shifting Sheds Light on Antibiotic Resistance February 18, 2022 MIT chemists have discovered how the structure of the EmrE transporter changes as a compound moves through it.

SURFSIDE, FL--(Marketwired - Mar 27, 2014) - NanoAntibiotics (OTCBB: NNAB) (the "Company"), a development stage nano-biotechnology company focused on the discovery, development, and commercialization ...

Efflux pump inhibitors: Bulking up to beat bacteria Researchers from SANKEN, The Institute of Scientific and Industrial Research at Osaka University provide new insights into the relationship ...

The molecular structure of the MmpL4 efflux pump in Mycobacterium tuberculosis reveals a coiled-coil domain essential for exporting the siderophore mycobactin and for bedaquiline resistance.