That property, plus some bulky substituents, guide nucleophiles such as Grignard reagents to preferentially attack this unusually electrophilic nitrogen. A single attack on an imine can lead to ...

These compounds are therefore electrophilic — attracted to areas of negative charge, such as those in nucleophilic molecules (Y −). Ketones and imines are thus prone to attack by nucleophiles.

The problem, however, is that we don't know exactly how most reactive electrophilic drugs work, which makes it difficult to predict their effects and outcomes, and efficiently design new ones.