The vectors of around 18,000 experimentally validated enzyme-substrate pairs ... (2023). A general model to predict small molecule substrates of enzymes based on machine and deep learning.

We identified small-molecule dimer disruptors that inhibit an essential dimeric protease of human Kaposi's sarcoma–associated herpesvirus (KSHV) by screening an α-helical mimetic library. Next ...

Exo Therapeutics raised $78 million in series B financing to develop a new strategy for drugging enzymes. Many drugs work by blocking target enzymes’ active sites, which perform reactions like ...

Researchers at the University of Illinois Urbana-Champaign have discovered important new clues in the mystery of how an ...

Professor Schwabe explained: "Previously our team had discovered that the activity of the enzymes in co-repressor complexes is regulated by a small molecule called inositol phosphate.

“We thus decided to engineer this parent enzyme.” The P450 BM3 constructs lactams through intramolecular C-H amidation, she says. “The substrate is a chain-like molecule with C-H bonds and a terminal ...

The substrate goes through a chemical reaction and changes into a new molecule called the product — sort of like when a key goes into a lock and the lock opens. Since most reactions in your body’s ...

Two-step nanocage: Individual enzymes (orange and green) are first attached to half-cage structures. Half cages are then assembled into full cages, where reactants are brought into close proximity ...

New knowledge about the mechanism of specific protein complexes in the body could help in the development of better drugs for the treatment of diseases such as cancer and Alzheimer's.

An experimental compound empowers an enzyme to help process acetaldehyde, a toxic metabolite of alcohol, according to new research supported by the National Institute on Alcohol Abuse and Alcoholism ...