Hypoxic macrophages-derived Wnt1 activates Wnt signaling pathways in epithelial cells. Macrophages in the mucosa are strategically located to interact with epithelial cells.

This study reveals that neutrophil extracellular traps (NETs) drive macrophage-derived chemokine production (CXCL9/10/11) to promote CD8+ T cell ...

Macrophages are immune cells that are found in every organ of the body. The research team, led by Thomas Weichhart of MedUni Vienna's Center for Pathobiochemistry and Genetics and coordinator of the ...

It highlights macrophages for the first time as "metabolic factories" that support the metabolism of other cells, which is critical for efficient self-renewal of the intestinal epithelium.

Loss of a key immune protein disrupted cell signaling and defense, revealing a novel driver of chronic airway inflammation in ...

Myeloid-epithelial-reproductive tyrosine receptor (MerTK), a receptor on the surface of the cardiac macrophage, is key to phosphatidylserine-triggered activation and was previously shown to be ...

One surprising finding from this imaging was that the infected T cells seemed to target epithelial cells directly above macrophages. "The macrophage just stays still, ready to get the virus when ...

Infection of the respiratory system by diseases like COVID-19 and flu causes damage to the epithelium. During the healing process, regenerative cells are typically kept in check by macrophages, as ...

image: TB bacteria infect host macrophages in a larval zebra fish and prod epithelial cells to produce MMP9, a signaling protein associated with worsening infection.

Macrophages have been implicated in mammary gland funct. ... 3D imaging of virgin mammary ducts in vivo, revealing the nature of DM–epithelium interactions. Functionally, DMs proliferate in pregnancy ...

“Although alveolar epithelial cell dysfunction may initiate the development of IPF, our findings suggest that repeated epithelial cell injury is not required for the progression of fibrosis.” “We ...