Escaping the endosome. Unfortunately, even when LNPs reach their target cells, the nanoparticles are typically captured by endosomes—tiny protective sacs within the cell.

The FDA has issued a Complete Response Letter to Sesen Bio regarding the BLA for Vicineum (oportuzumab monatox-qqrs) for BCG-unresponsive non-muscle invasive bladder cancer.

Huntington's disease is caused by CAG trinucleotide expansions in the gene encoding huntingtin. N- terminal fragments of huntingtin with polyglutamine produce aggregates in the endosome-lysosomal ...

Interactions between Bacillus thuringiensis Berliner and its beta-exotoxin, thuringiensin, were evaluated in neonate larvae of Spodoptera frugiperda (J. E. Smith). The median lethal concentration of B ...