In addition to discoveries of leptin's role in cellular fat metabolism, Kim and his colleagues also have found a way to produce longer-lasting leptin. "Native leptin produced in the body is short ...

That’s in part because typically your body automatically makes less leptin when you lose fat mass. Though, ... Scientists thought people with obesity might be like that leptin-lacking mouse.

Using mouse models, ... "This is done in order to block the action of the leptin fat cells produce." May-Yun Wang, lead investigator and instructor of internal medicine at UT Southwestern, ...

Sometimes your brain tells you to eat more, even when you have plenty of leptin and lots of fat cells. ... Scientists thought people with obesity might be like that leptin-lacking mouse.

Anil Oza is STAT’s 2024-2025 Sharon Begley Science Reporting Fellow. You can reach Anil on Signal at aniloza.16. The hormone leptin was discovered 30 years ago to much fanfare. Scientists hoped ...

Using mouse models, ... "This is done in order to block the action of the leptin fat cells produce." May-Yun Wang, lead investigator and instructor of internal medicine at UT Southwestern, ...

We know that too much body fat is generally bad for our cardiovascular system, and now scientists are learning more about how too little fat yields some of the same damage. Topics.

The results were striking: “Obese mice fed a high-fat diet and treated with the mTOR inhibitor rapamycin lost significant amounts of weight, which—similar to leptin treatment in leptin ...

Ob/ob mice, for example, have elevated plasma insulin. But FAT-ATTAC ob/ob mice, which not only have no leptin, but no fat, have only about half the normal insulin. The fatless FAT-ATTAC ob/ob mice ...

OBJECTIVE: To study the influence of thyroid hormones on the relationship between serum leptin and fat mass, as well as on energy and macronutrient balance. DESIGN: Rats with different thyroid ...

Body fat hormone leptin influences runner's high ... Past research has shown that leptin signaling in the brain's reward center inhibits wheel running in a rat model of anorexia-induced hyperactivity.

L eptin is a hormone released by fat cells in adult organisms, and researchers have largely focused on how it controls appetite. In a study published May 18 in Science Signaling, the authors show that ...