Josiah Willard Gibbs, an American mathematician, first described Gibbs free energy in the 1870s. According to Gibbs, free energy is the total energy of a system that is available to perform useful ...

The thermodynamic approach applies the binding phenomenological equation. Study findings. The Gibbs energy of binding of the SARS-CoV-2 Omicron subvariant BA.2.75 was -49.41 kJ/mol, while that of ...