One HDAC target is MEF2, a key muscle transcription factor. Given that HDAC–MEF2 interaction is known to repress MEF2 (ref. 6) activity and MEF2 has been implicated in cardiac hypertrophy 6, ...

Calcium/calmodulin-dependent protein kinase (CaMK) signalling, which stimulates myogenesis 5 and prevents formation of MEF2–HDAC complexes 4, also induces nuclear export of HDAC4 and HDAC5 by ...