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Nature22y
In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A | Oncogene - Nature
One of the two isoforms of the human insulin receptor (isoform A or IR-A) binds IGF-II with high affinity and is predominantly expressed in fetal tissues and malignant cells. We evaluated the ...
ascopubs.org15y
Insulin-like growth factor (IGF) and epidermal growth factor (EGF) receptors as therapeutic targets in metastatic renal cell carcinoma.
e15113 Background: Renal cell carcinoma (RCC) is associated with mutation or loss of function of the von Hippel-Lindau gene resulting in hypoxia-inducible factor 1-alpha accumulation and production of ...