Researchers investigated the complement component 1q (C1q) binding and subsequent complement activation by neutralizing antibodies (nAbs) produced following COVID-19 vaccination.

The authors of a research paper published in the journal Frontiers in Immunology used Sandwich ELISA tests to determine the distribution of IgG sub-classes and complement activation levels in ...

Myasthenia gravis (MG) results from autoimmune antibodies against the post-synaptic neuromuscular junction with three major ...

IgG antibodies activate blood platelets and contribute to the severity of anaphylaxis Date: May 15, 2018 Source: Institut Pasteur Summary: While it was already known that IgE antibodies can ...

While it was already known that IgE antibodies can trigger allergic reactions, scientists recently demonstrated that IgG antibodies play an active role in the severity of anaphylactic shock by ...

Circulating cold-insoluble complexes, observed in 11 of 31 patients with systemic lupus erythematosus (SLE), consisted mainly of immunoglobulin G and the C′lq component of complement and did not ...

“ARO-CFB also demonstrated dramatic reductions in measures of alternative complement pathway activation, with mean reductions at or approaching 100% in AH50 and Wieslab AP at multiple dose levels.

To determine whether or not the complement system might be implicated in the systemic reactions, the ability of the IgG anti-IgA to fix complement was examined.

Non-structural protein 1 (NS1) can facilitate viral RNA replication and virus assembly, inhibit complement, activate platelets and immune cells, and induce vascular endothelial dysfunction in a ...