Between 1999 and 2006, all St. Jude patients with bilateral Wilms tumor exhibiting favorable histology (cell characteristics) underwent bilateral nephron-sparing surgeries, or partial nephrectomies.

Histology showed nephrosclerosis with diabetic changes in 9 patients, nephrosclerosis with focal segmental glomerular sclerosis in 4 patients, and nephrosclerosis alone in 4 patients. Only 1 ...

Transcription factors AP-2α and AP-2β regulate distinct segments of the distal nephron in the mammalian kidney. Nature Communications , 2022; 13 (1) DOI: 10.1038/s41467-022-29644-3 Cite This Page : ...

This commentary discusses nephron protection in diabetic kidney disease and describes the way in which renin–angiotensin system inhibitors and the sodium–glucose cotransporter 2 inhibitor ...

Mouse kidney nephron progenitor cells (purple) forming the developing nephron tubules (yellow) of the kidney’s filtering units, the nephrons. (Image by Helena Bugacov/McMahon Lab) ...

By spatially linking lipid composition to anatomical and functional regions of the kidney, we were able to effectively generate a molecular bar code for each component of the human nephron." ...

Both studies focus on the progenitor and stem cells that form the kidney's filtering units, known as nephrons, in embryonic mice. "Nephron progenitor cells cease to exist by the time humans are ...

Unfortunately, the nephron formation is interrupted when babies are born preterm, which consequently puts them at higher risk of developing kidney disease later in life. "We never make another ...