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Before you start trying to unlock your mouse, it's worth checking whether your whole PC has frozen or not. A good test for this is to hit the Caps Lock or Num Lock keys on your keyboard.
Mouse Lock is a free, open-source software for Windows 10 desktop & laptop that can dim the desktop and lock mouse cursor & pointer, thereby locking down the monitor.
BlueLife KeyFreeze lets you lock keyboard and mouse. Microsoft makes it possible to lock Windows by pressing Win+L, but it takes the user out of the OS.
That also means it's possible to lock mouse functionality by accident. If that happens, the directions above provide easy ways to unlock a laptop with a touchpad. However, ...
The Windows taskbar is one of the most important parts of the Windows 7 and Windows 8 user experience and customizing it to your specific needs will go a long way in making Windows easier to use.