Macrophages are immune cells with a split personality: some fight tumors, while others help them grow. In breast cancer, most ...

More information: Yinghua Zhu et al, Cancer cell-derived arginine fuels polyamine biosynthesis in tumor-associated macrophages to promote immune evasion, Cancer Cell (2025). DOI: 10.1016/j.ccell ...

Arginine is a semi-essential or conditionally essential amino acid that can be produced within the body, but some conditions can render them essential, when they must be procured through the diet.

In parallel, novel studies investigating immunometabolic disorders have demonstrated that agmatine can modulate macrophage polarization, shifting the balance toward an anti-inflammatory M2 phenotype.

Chinese scientists have revealed a hidden metabolic partnership between breast cancer cells and immune cells that drives aggressive tumor behavior and resistance to immunotherapies. The study sheds ...

The polarization response of macrophages seeded on titanium materials is influenced by multiple factors, and artificial intelligence can assist in extracting the key features of implant materials ...

“We reveal that the metabolic interplay between cancer cells and macrophages plays a dominant role in arginine-driven breast cancer progression,” the researchers wrote in a paper published in ...

This study unveiled the role of Lrrk2 gene in regulating macrophage polarization and immune response. This finding provides significant insights into the role of Lrrk2 in M1 macrophage modulation ...

Varsha demonstrates macrophage polarization control using hMSC-inspired microgel scaffolds Published:3/23/2021 3/23/2021 Varsha Rao and recently-graduated Dr. Alex Caldwell published this month in ...