Macrophages are able to polarize to proinflammatory M1 or alternative M2 states with distinct phenotypes and physiological functions. How metabolic status regulates macrophage polarization remains ...

Macrophages are immune cells with a split personality: some fight tumors, while others help them grow. In breast cancer, most ...

In a surprising twist on cellular metabolism, scientists have uncovered a noncanonical role of the metabolic enzymePHGDH in ...

Adenosine deaminase 2 (ADA2) plays a critical role in immune regulation, particularly in monocyte differentiation and ...

New metabolic mechanisms have been discovered that regulate macrophage polarization - the unique ability of these immune cells to change their specialization depending on the required task. The ...

A group of researchers from Washington University in St. Louis, Agios Pharmaceuticals and ITMO University has discovered new metabolic mechanisms that regulate macrophage polarization - the unique ...

Human exposure to toxic particles drives various diseases. Examples include gout, an acute arthritis driven by monosodium urate crystals, or MSUc; CPPD disease, another inflammatory joint disease ...

Background: The immune microenvironment of breast cancer is richly infiltrated with macrophages, yet modulation targeting macrophage polarization has failed to achieve significant clinical ...

If this pathway is inhibited by specific substances the M2 polarization and proliferation is downregulated. This has direct consequences for the understanding of TAM´s and the treatment of cancer.