In F2 screens, a mutagen, such as ethylnitrosourea (ENU), is used to generate hundreds of point mutations in the male pre-meiotic germ cells (spermatogonia). ENU-treated males are crossed to wild ...

The far-reaching effects of mutagens on human health Date: December 21, 2020 Source: Arizona State University Summary: Mutagenic threats to a cell's subtle machinery may be far more widespread ...

Cancer is caused by the growth of an abnormal cell which harbours DNA mutations. A few years ago, scientists have identified an important mutagen which lies in our own cells: APOBEC, a protein ...

Physical mutagens, mostly ionizing radiation, can increase the natural mutation rate by 1,000 to 1 million fold, and have been widely used to induce heritable genetic changes. More than 70 per cent of ...

Mutagenic threats to a cell's subtle machinery may be far more widespread than previously appreciated. In a new study, Michael Lynch and his colleagues demonstrate that DNA mutation itself may ...