In the case of unmyelinated axons, the nerve impulse, or action potential, moves along the axon continuously. By contrast, in myelinated nerve fiber, currents can only occur where the axonal ...

In contrast, among the myelinated nerve fibers, axons are mostly covered by myelin sheaths, and transmembrane currents can only occur at the nodes of Ranvier where the axonal membrane is exposed.

image: (a) Schematic illustration of the core-shell configuration of the myelinated axon with efficient neural action potential transmission capability.

TREK-1 and TRAAK are principal K+ channels at the Nodes of Ranvier for rapid action potential conduction on mammalian myelinated afferent nerves ... reported that two ion channels—TREK-1 and TRAAK—act ...

Support of myelinated axons through a myelin sheath requires that the architecture of myelin be intact, including the tight communication channels between the oligodendrocytes and axons.

Myelinated axons, in particular, are highly dependent on metabolic support because they have little access to nutrients on their own. Support of myelinated axons through a myelin sheath requires that ...

In unmyelinated axons, the action potential travels along the axon in a continuous manner, whereas in myelinated axons, a current is only found at the nodes of Ranvier, where the membrane of the ...