A new study using induced pluripotent stem cell (iPSC) technology links astrocyte dysfunction to Parkinson's disease (PD) pathology. The study highlights the role of brain astrocyte cells in PD ...

Tau protein is essential for microtubule stability and neuronal function. The protein’s disfunction is linked to several ...

"These cases are broadly referred to with the term 'body-first PD.' To identify the organs where α-synuclein pathology begins, we stained the peripheral organs and found that the kidneys were ...

Damaged mitochondrial DNA (mtDNA) initiates and spreads Parkinson's disease (PD) pathology, potentially opening new avenues for early diagnosis, disease monitoring, and drug development.. While ...

Overall, 36 percent of PD-associated species had greater than twofold change in abundance, reflecting a 100 percent to 750 percent increase or decrease in PD versus the healthy control group. “This ...

UB-312 is the first Parkinson's candidate to reduce pathology as measured by a seed amplification assay, and suggest clinical improvement on motor experiences of daily living. Data demonstrates ...

It separates, with a stunning 90 percent specificity, those who have evidence of PD pathology in their cells from those who do not. It does so even before the emergence of symptoms, ...

Deposition of α-synuclein in the kidneys of PD patients. Credit: Yuan et al. Nature Neuroscience (2025). DOI: 10.1038/s41593-024-01866-2.