TRPC6 associates with the podocyte actin cytoskeleton and experiments, both in vitro and in vivo, suggest that induction of TRPC6 directly affects cytoskeletal organization in these cells. 64 A ...

Other therapies have been tried, including alkylating agents, plasmapheresis, and even the anti–B-cell monoclonal antibody rituximab, which also stabilizes the podocyte actin cytoskeleton, 96 ...

The podocyte is a key target of injury in a number of renal diseases. Although some current therapies—including glucocorticosteroids and calcineurin inhibitors—have potent effects on the ...

In podocytes, as in muscle and adipocytes, GLUT4 translocation is dependent on an intact actin cytoskeleton to facilitate movement of GLUT4-rich vesicles to the periphery of the cell.

The hypothesis that podocyte loss is a culprit in the development of glomerulosclerosis was formulated more than 30 years ago 39,41 and has subsequently been proved both experimentally and ...

SETD2, known for its involvement on gene expression, also can affect functions controlled by the cytoskeleton, such as movement, metastasis and migration, which are very important for cancer cells.

The actin cytoskeleton is a dynamic network made up of actin polymers and associated actin binding proteins. The actin cytoskeleton was originally isolated as a component of the actomyosin complex ...

Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity. Cancer Research , 2018; 78 (19): 5631 DOI: 10.1158/0008-5472.CAN-18-0441 Cite This Page : ...

In this project, we showed that the actin cytoskeleton of NK-resistant tumor cells accumulates at the IS. Using the high-throughput The ImageStream®X MKII Imaging Flow Cytometer and applying specific ...

Study identifies key protein that helps regulate the actin cytoskeleton. A recent study led by Assistant Professor of Gerontology Ryo Sanabria has identified a key protein that helps regulate the ...

GLUT1 is found at the podocyte cell surface and in intracytoplasmic vesicles (v). ... Preincubation of podocytes with 10 µmol/l cytochalasin D disrupted the F-actin cytoskeleton in vitro.

More information: Antoun Al Absi et al, Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity, Cancer Research (2018). DOI: 10.1158/0008-5472 ...