A deep-learning model trained on human data reveals that promoter mutations may explain a significant portion of unsolved ...

DNA transcription is the vital first step needed for switching on our genes. For a gene to be switched on, it must be acted upon by an enzyme called RNA polymerase. This is a molecular machine which ...

Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can ...

More information: Elina Wiechens et al, Gene regulation by convergent promoters, Nature Genetics (2025). DOI: 10.1038/s41588-024-02025-w Provided by Leibniz-Institut für Alternsforschung - Fritz ...

DNA contains genetic material called promoters, which essentially switch genes on and off. Because DNA is twisted and coiled in a 3D shape, these promoters can control genes that are located far ...

At specific places called promoters, a complex molecular machinery starts transcribing DNA sequences into mRNA. Interestingly, most genes contain multiple possible sites where transcription can start ...

Decoding plant gene expression: A deep dive into promoters and terminators for advanced bioengineering. In high-precision bioengineering and synthetic biology, the fine-tuning of gene expression ...

In head-to-head comparisons, the new promoters outperformed the widely used GRK1 promoter in both expression strength and specificity. “This study addresses one of the biggest hurdles in IRD treatment ...

DNA sequences that regulate expression of the insulin gene are located within a region spanning ~400 bp that flank the transcription start site. This region, the insulin promoter, contains a ...

What are Promoters and Enhancers? The genome contains a large number of non-coding DNA regulatory elements, including silencers, insulators, promoters and enhancers, which play an important role in ...

Cite this: Comparative Analysis of Insulin Gene Promoters: Implications for Diabetes Research - Medscape - Dec 01, 2006. Abstract and Introduction Insulin Gene Expression ...