The secondary structure of the mRNA target site has ... Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494–498 (2001).

Plants and fungi can use conserved RNA interference machinery to regulate each other’s gene expression—and scientists think they can make use of this phenomenon to create a new generation of ...

With small molecules, which make up an estimated 90% of approved medicines 1, each new medicine requires in-depth knowledge of the structure ... an approach called RNA interference (RNAi) are ...

View Full Profile. Learn about our Editorial Policies. The natural RNAi mechanism can be directed by either short interfering RNA (siRNA) or microRNA (miRNA). 1 There are four key steps in the RNAi ...

In 1998, Andrew Fire and Craig Mello published a groundbreaking study demonstrating that double-stranded RNA (dsRNA) could silence genes in the nematode Caenorhabditis elegans. This discovery laid the ...

RNA interference (RNAi) acts like a "gene switch," selectively silencing specific genes. It uses specialized RNA molecules, such as small interfering RNA (siRNA) or microRNA (miRNA), to block ...