Gaining New Insight on Receptor Tyrosine Kinase Signaling and Pharmacology Domain Therapeutics describes a biosensor platform that allows for real-time monitoring of signal transduction pathways ...

The receptor tyrosine kinase c-Met continues to signal following its internalization, recruiting the small GTPase Rac to stimulate cell migration. Ménard et al.show that this Rac signalling ...

Original Paper Published: 28 September 2000 TNF down-regulation of receptor tyrosine kinase-dependent mitogenic signal pathways as an important step in cytostasis induction and commitment to ...

HR-positive/HER2-negative is the most common subtype of breast cancer in women. HR-positive/HER2-negative metastatic breast ...

Bruton tyrosine kinase (BTK) inhibitors are an emerging type of DMT for MS; many of these agents are being tested in clinical trials globally for relapsing, primary, and secondary progressive MS.

The table below is a review of notable updates that occurred in June 2025 for investigational products in development (not an inclusive list). Click on the status to view our full coverage.

Tyrosine kinase inhibitors block tyrosine kinase (K), thereby preventing further progression through the transduction pathway. As a result, cell division and tumor growth are stopped.

On February 5, 2024, a new research paper was published in Oncotarget, entitled, “Neurotrophic-tyrosine receptor kinase gene fusion in papillary thyroid cancer: A clinicogenomic biobank and ...

Savolitinib blocks atypical activation of the MET receptor tyrosine kinase pathway that occurs because of mutations (such as exon 14 skipping alterations or other point mutations), gene ...

The ephrin B2 receptor tyrosine kinase is a regulator of proto-oncogene MYC and molecular programs central to Barrett’s neoplasia. Gastroenterology. 2022;0 (0). doi: 10.1053/j.gastro.2022.07.045 This ...

The epidermal growth factor receptor (EGFR) is a target found in high concentrations in several solid tumors including lung, breast, colorectal, and brain. Tyrosine kinase inhibitors, such as ...