There were more than 48,000 organ transplants in the United States last year. They’re commonplace now, but the practice was considered experimental only a half-century ago.

Researchers identified a natural 'brake' within the innate immune system: the inhibitory receptor Siglec-E (SigE) and its human counterparts, Siglec-7 and Siglec-9. This receptor helps prevent ...

Achieving tolerance to transplanted organs should solve both problems ... In virtually all animal models, T cells are required for transplant rejection (Fig. 1), and so the focus of tolerance ...

If you're living with a transplant, "rejection" is a word that can send shivers up your spine. But organ rejection is often not as bad as it sounds. As scary as the word may be, it doesn't ...

Discovery of innate immune receptor "brake" Siglec-E offers a novel therapeutic target to prevent organ transplant rejection ...

The result was PIPSA, which stands for Predicting Indirect Peptides with Solvent Accessibility. PIPSA is a model that ...

there were “no signs of immune rejection,” they wrote in the paper. The transplant came after about a decade of earlier studies and transplants by Wang and his team of gene-edited organs from ...

Japanese researchers said they have produced three piglets cloned from a pig that was genetically modified to prevent rejection of its organs in transplants to humans. PorMedTec Co., a Kawasaki ...

Kidneys are the most transplanted ... is rejection of the transplant. This is a defensive reaction of the body against the foreign tissue, which can lead to a complete loss of organ function ...

Kidneys are the most transplanted organ in Germany. According to the German Organ Transplantation Foundation, a total of 1,514 kidneys were transplanted after post-mortem organ donation in 2023, out ...