Also show is a box plot of mito-roGFP measurements from VTA dopaminergic neurons following genipin application; genipin had no effect on these measurements (P > 0.05, n = 5). b, Left: TMRM ...

The protein, called roGFP, developed by Jim Remington at the University of Oregon, contains two cysteine residues that form a disulfide bond under oxidative conditions. When the bond forms, the ...

Since roGFP lights up when oxidized, the protein provided a way to directly visualize the oxidation state of mitochondria. Guzman and colleagues examined brain slices from the transgenic mice with two ...

Special Issue – Hepatic and Pancreatic Systems The cover shows bioimaging of mouse liver oxidative stress after partial hepatectomy. roGFP (reduction/oxidation-sensitive green fluorescent ...

Redox processes play an important role in cellular physiologyand pathology. A particularly powerful tool for the monitoringof cellular redox changes are genetically-encoded biosensorsbased on redox ...