LDO effectively reprograms macrophage polarization, alleviates CCL2-mediated cytokine storms and acute lung injury, and significantly improves the survival rate in sepsis animal models (Fig. 1).

This study unveiled the role of Lrrk2 gene in regulating macrophage polarization and immune response. This finding provides significant insights into the role of Lrrk2 in M1 macrophage modulation ...