These findings show, for the first time, that Gal-1 can directly bind to NRP1 on endothelial cells, and can promote the NRP1/VEGFR-2-mediated signaling pathway as well as NRP1-mediated biological ...

Human exposure to toxic particles drives various diseases. Examples include gout, an acute arthritis driven by monosodium ...

PlGF/VEGFR-1 signaling promotes macrophage polarization and accelerated tumor progression in obesity. Clinical Cancer Research , 2016; DOI: 10.1158/1078-0432.CCR-15-1839 Cite This Page : ...

Inhibiting the PIGF/VEGFR-1 signaling regressed tumor growth in obese, but not in lean mice, the author report. Obesity is a confirmed risk factor for the development of several cancers, including ...

Sasanka Ramanadham, Ph.D., and researchers published “Selective Reduction of Ca2+-Independent Phospholipase A2β (iPLA2β)-Derived Lipid Signaling from Macrophages Mitigates Type 1 Diabetes ...

More information: Victor Fattori et al, Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice, Science Translational ...

Suppression of metastasis-promoting microenvironment by blocking signaling pathway may be ... the PlGF/ VEGFR-1 pathway may be ... immunosuppressive tumor-associated macrophages.

As an endogenous agonist of OXGR1, AKG has been shown to have important regulatory roles in extending lifespan, maintaining intestinal health, reducing the risk of obesity, and activating macrophages.

In diseases due to exposure to toxic particles like gout, macrophages elicit separate pathways for inflammation and lysosomal ...