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These findings show, for the first time, that Gal-1 can directly bind to NRP1 on endothelial cells, and can promote the NRP1/VEGFR-2-mediated signaling pathway as well as NRP1-mediated biological ...
PlGF/VEGFR-1 signaling promotes macrophage polarization and accelerated tumor progression in obesity. Clinical Cancer Research , 2016; DOI: 10.1158/1078-0432.CCR-15-1839 Cite This Page : ...
Suppression of metastasis-promoting microenvironment by blocking signaling pathway may be ... the PlGF/ VEGFR-1 pathway may be ... immunosuppressive tumor-associated macrophages.
Inhibiting the PIGF/VEGFR-1 signaling regressed tumor growth in obese, but not in lean mice, the author report. Obesity is a confirmed risk factor for the development of several cancers, including ...
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