Mining vector genomes to improve global health. April 22, 2016 Share: ... Vector control is one the best methods of tamping down re-emerging diseases such as Zika, West Nile virus and dengue. But ...

Valoctocogene roxaparvovec (AAV5-hFVIII-SQ) is an adeno-associated virus 5 (AAV5)–based gene-therapy vector containing a coagulation factor VIII complementary DNA driven by a liver-selective ...

GC301 was administered at a dose of 1.2×10 14 vector genomes per kilogram of body weight in an intravenous infusion over a period of 55 to 77 minutes. Prophylactic prednisolone was also administered.

According to Gentile, the cell line routinely achieves yields exceeding 4×10¹⁴ vector genomes per liter (vg/L) across a range of serotypes, which are levels comparable to leading commercial ...

Across five different T cell donors, transduction efficiencies were variable, but gene editing was consistently high. These findings demonstrate that the TOP vector can efficiently transduce and edit ...

They received 3×10 14 vector genomes per kilogram bodyweight (vg/kg) by intravenous administration. This is among the highest doses of any AAV ever administered to either adults or children ...

The patient received 3E15 vector genomes of gene therapy NGN-401 on Nov. 5 as part of the high-dose arm of Neurogene’s ongoing phase 1/2 open-label, pediatric study. She developed a fever before ...

In the open-label, single-group, multicenter GENEr8-1 trial, participants received a single infusion of 6 × 10 13 vector genomes of the gene therapy per kilogram of body weight. Study findings at ...

Mining vector genomes to improve global health Sarah E Anderson April 22, 2016 Agriculture, Life Sciences. ... Vector control is one the best methods of tamping down re-emerging diseases such as Zika, ...