Next, Hydroxymethylglutaryl-CoA synthase can form the molecule HMG-CoA from another acetyl-CoA and the previously made acetoacetyl-CoA. The two proteins that facilitate this key enzyme activity ...

The synthesis of cholesterol begins with a molecule of acetyl CoA and one molecule of acetoacetyl-CoA, which are dehydrated to form 3-hydroxy-3-methylglutaryl CoA (HMG-CoA).

Organisms across all kingdoms of life crucially rely on a molecule called acetyl-CoA that fuels essential biochemical processes in cells, such as the production of fatty acids and cholesterol ...

Immune cells use two different routes to produce acetyl-CoA, an essential metabolite required to fight infection and cancer, reports a study led by Van Andel Institute scientists.. The findings, ...

The resulting acetyl-CoA molecules can be used to produce a desired chemical with higher carbon efficiency. The researchers dubbed their new hybrid pathway non-oxidative glycolysis, or NOG. "This ...

UCLA chemical engineering researchers have created a new synthetic metabolic pathway for breaking down glucose that could lead to a 50 percent increase in the production of biofuels.

More information: Chao Wu et al, Acetyl-CoA synthesis through a bicyclic carbon-fixing pathway in gas-fermenting bacteria, Nature Synthesis (2022). DOI: 10.1038/s44160-022-00095-4 Journal ...