Transduction with AAV.TRAIL gave rise to rapid expression of TRAIL, followed by induction of apoptosis, which could be inhibited by the caspase inhibitor z-VAD.fmk, in several human colon cancer ...

They used an adenovirus-associated virus (AAV) to deliver a gene editor for deleting SATB2 andshowed that the treated colon organoids became ileum-like and were able to survive when transplanted ...

In the study, "Single-AAV CRISPR editing of skeletal muscle in non-human primates with NanoCas, an ultracompact nuclease," published on the bioRxiv preprint server, researchers performed a ...

For decades, the Amphibious Assault Vehicle (AAV) has been a cornerstone of the U.S. Marine Corps, transporting troops and cargo from ship to shore. With its 29-ton combat weight, armored ...

Potent in vivo gene editing in skeletal muscle of non-human primates by a novel, ultracompact CRISPR system delivered via a single AAV vector.

The AAV-Ep+ capsid variant was identified through a massively parallelled and unbiased screen of a large-diversity AAV variant library administered to NHPs.

AAV Vectors AAVs are single-stranded DNA viruses that require co-infection with other viruses, mainly adenoviruses, to replicate. When used as gene therapy vehicles, researchers generate recombinant ...

Amid a reckoning for the gene therapy field, Vertex Pharmaceuticals has joined a growing list of companies paring back their research efforts around the adeno-associated virus (AAV) vectors used ...

TSP-1 reduced C3 and C5 cleavage and formation of the membrane attack complex, attenuating complement-mediated injury in AAV models.

The AAV-7A1 Amtrac is a US Transport Vehicle that seats up to six players. This Amphibious Assault Vehicle can drive on both land and sea, making it a very useful vehicle for bringing soldiers ...

Challenges in AAV titer Multiple methods have been developed and employed in recent years to improve genome titer and AAV quantitation.