Please discuss the unique mechanism of action of tarlatamab, a BiTE, and its treatment potential as subsequent therapy for SCLC, which has progressed after platinum-based chemotherapy. Please provide ...

Scaling of action potential (AP) duration (APD) in mammals of different size is a rather complex phenomenon, dominated by a regulatory type mechanism of ion channels expression. By means of ...

A generic cardiac ionic model employing membrane currents based on two-gate Hodgkin-Huxley kinetics is presented. Its generic nature allows it to accurately reproduce action potential waveforms in ...

Figure 1. Illustration of the EMI model domain. (A) Shows the approximate cylindrical geometry and associated mesh of a single myocyte of length 120 μm and diameter ranging from 13 to 14 μm (Nygren et ...

The deep learning network was trained using simulated action potential (AP) data and applied to classify cells into the drug-free and drugged categories and to predict the impact of ...

The manuscript entitled, "The Adhesion Function of the Sodium Channel Beta Subunit (β1) is Required for Cardiac Action Potential Propagation" describes combined experimental and computational studies ...

Rationale:Alternans is a risk factor for cardiac arrhythmia, including atrial fibrillation. At the cellular level alternans manifests as beat-to-beat alternations in contraction, action potential ...

Since publication of the first computational model of the cardiac myocyte action potential (AP) in 1960 (Noble, 1960), the range of biological processes described in models of the cardiac myocyte has ...

The plasma membrane of cardiac myocytes presents complex invaginations known as the transverse-axial tubular system (TATS). Despite TATS's crucial role in excitation-contraction coupling and ...