The adenovirus helper plasmid provides essential helper functions for AAV replication and packaging, whereas the AAV genome plasmid contains the therapeutic gene flanked by inverted terminal ...

ICVB-1042 is a chimeric oncolytic adenovirus, rationally designed with genomic modifications to confer tumor selective replication, broad tropism and enhanced tumor cell killing, as well as allow ...

The replication of potentially harmful adenoviruses can be significantly reduced in human cells in cell culture by using the so-called CRISPR-Cas9 system ("gene scissors") ...

Because the adenovirus proteins involved in genome replication are distinct from those involved in particle assembly and genome packaging, the researchers reasoned focusing on this virus would ...

Because the adenovirus proteins involved in genome replication are distinct from those involved in particle assembly and genome packaging, the researchers reasoned focusing on this virus would ...

Viruses can teach us a lot about ourselves: How our bodies and cells work, and what can go wrong. Fred Hutch virologist Dr. Daphne Avgousti talks about her work on herpesvirus and adenovirus and how ...

This homology allows for homologous recombination events to happen during the production process, leading to the risk of generating replication-competent adenovirus (RCA) (Figure 1B, left). 2 The ...

Adenovirus-vector vaccines Like mRNA, Adenovirus-vector vaccines also use a specific genetic code from the “spike antigen” to protect the body against COVID-19, but it is deployed differently.

For instance, the AstraZeneca vaccine and Covishield use an adenovirus that causes common cold in chimpanzees. Russia’s Sputnik V uses human adenoviruses engineered to prevent replication.

Anvisa’s president and the agency’s Management-General for Medications Gustavo Mendes said that the information on adenoviruses capable of replication could be found in the document submitted ...