In biology textbooks and beyond, the human genome and DNA therein typically are taught in only one dimension. While it can be ...

Antibody–siRNA conjugates (ARCs) are a type of promising drug modalities for cancer therapy. However, initial reports of ARCs present the gene knockdown effect only in limited tissues (e.g., muscles) ...

When people think of DNA, they usually think of genes, the parts that code for proteins and drive inherited traits. But there ...

Database search is the most commonly employed method for identification of peptides from MS/MS spectra data. The search involves comparing experimentally obtained MS/MS spectra against a set of ...

Although scientists have made significant progress in understanding the disease, there’s still no cure. That’s partly because ...

Fit-ligand is a computational algorithm that enables accurate modeling of multiple conformational states of ligands in X-ray crystallography and cryo-electron microscopy (cryo-EM).

Arano and co-workers (Arano et al. (1999) Cancer Res. 59, 128−134) have synthesized peptides with an N-terminal radioiodinated hippuric acid and a C-terminal lysine linked to antibody fragments via ...

Antibody-drug conjugates (ADCs) represent a mechanistically defined class of targeted therapeutics that combine monoclonal antibodies with cytotoxic payloads to achieve selective delivery to ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

Conclusions The crystal structure and biochemical analyses of the Hsp33 fragments with constitutive chaperone activity suggest a novel redox switch mechanism.