The sugar-phosphate backbone forms the structural framework of nucleic acids, including DNA and RNA. This backbone is composed of alternating sugar and phosphate groups, and defines directionality ...

Natural nucleic acids like DNA and RNA have a sugar-phosphate "backbone" and nitrogen-based components; while the nitrogen-based components in SNA and L-aTNA remain the same, they have an amino ...

Nucleic acid comes in two natural forms called DNA and RNA. Nucleic acid is essential for all forms of life, ... This will repeat to create a chain held together by a sugar-phosphate backbone.

How to cite this article: Amrane, S. et al. Backbone-independent nucleic acid binding by splicing factor SUP-12 reveals key aspects of molecular recognition. Nat.

Peptide nucleic acids (PNAs) are artificial polymers that were originally invented in 1991 to be synthetic mimics of DNA. Instead of having a deoxyribose phosphate backbone like DNA, PNA has a ...

Glycol nucleic acid (GNA; shown, B = base)—the analog introduced by Meggers, postdoc Lilu Zhang, and collaborator Adam Peritz—has just three carbon atoms and one stereocenter in the backbone ...

Nucleic acids are the backbone of molecular biology research. As such, preservation of their integrity and purity is fundamental for genomic research. Low quality samples can lead to inconsistent ...

Xeno nucleic acids are essential for the development of nucleic acid-based drugs. To be effective, they need to be able to stably bind to natural RNA (a cellular single-stranded version of the DNA ...

A biochemical breakthrough using simple carbon atoms, by Ken Yamada, Ph.D., and Anastasia Khvorova, Ph.D., has dramatically improved the stability and efficacy of a potential oligonucleotide ...

Summary Peptide Nucleic Acid (PNA) is a synthetic polymer similar to DNA or RNA. PNA can be said to have been born in Denmark, where it was originally developed by Peter E. Nielsen (University of ...

These two nucleic acids have different names because they're built from different sugars: DNA uses deoxyribose sugars for a backbone of its double helix, while RNA uses ribose.

The two U.S. FDA approved oligonucleotide-based drugs on the market both have a modified chemical backbone made of ... it is enabling are detailed in a Review article in Nucleic Acid ...