They were able to obtain high-resolution structures of Cap5 from Pseudomonas in a complex with cyclic nucleotides, uncovering the key to their activation.

Cap5 is a key protein that becomes activated by cyclic nucleotides (small signaling molecules) to destroy the bacterial cell’s own DNA.

Researchers at the Icahn School of Medicine at Mount Sinai have identified a new approach to controlling bacterial infections.

A single β-lactam exposure rapidly drives stable multidrug resistance in RecA-deficient bacteria through an SOS-independent mechanism involving oxidative stress-induced mutagenesis and ...

Could a gene regulatory network in gut microbes have evolved its elaborate and tightly regulated molecular machinery only to pump out antibiotics indiscriminately? Researchers from the Institute of ...

Bacteria can rapidly evolve resistance to antibiotics by adapting special pumps to flush them out of their cells, according to new research. Antimicrobial resistance is a growing problem of global ...

OptE is predicted to be a transmembrane effector protein that binds cyclic nucleotides. optSE potently restricted phage replication but mutant phages that had loss-of-function mutations in anti-CBASS ...

Tsuji and Sutton aim to define the contributions of hypermutators to antibiotic resistance. In collaboration with Anthony Berdis, professor of chemistry at Cleveland State University who previously ...

How bacteria nearly killed by antibiotics can recover — and gain resistance A protein that pumps toxic chemicals from the microbes allows some of them to resurge ...

Binding of NucC trimers to a cyclic tri-adenylate second messenger promotes assembly of a NucC homohexamer competent for non-specific double-strand DNA cleavage. In infected cells, NucC activation ...