Using these processing conditions, we conducted a flow cytometry screen on fresh whole blood samples from humans and NHPs (total n=9, consisting of n=2 biological replicates per NHP species and n=1 ...

Affinity for BCMA is two orders of magnitude higher than for CD3, ensuring that the bispecific antibody recruits and activates T cells while minimizing non-specific T cell activation and reducing ...

Affinity chromatography remains one of the main methods for purifying antibodies, enabling high specificity and yield. Whether working with recombinant monoclonal antibodies or polyclonal antibodies ...

An overview of the articles in this Focus issue on therapeutic antibodies. Over the past 10 years, the market for monoclonal antibodies has grown exponentially. This focus issue brings together ...

Antibodies are secreted immunoglobulin molecules produced mainly by plasma cells. The antigen-binding site of the antibody has a unique structure that allows it to bind antigen in a highly ...

The FDA has started a review of MSD's respiratory syncytial virus (RSV) antibody clesrovimab, with a verdict due in the middle of next year. If approved by the 10th June action date, clesrovimab ...

This repository contains the antibody-antigen test cases, with unbound and bound structures, for Docking Benchmark 5.5. This dataset is a major update of Docking Benchmark 5.0, which was released in ...

Antibodies are important for protection against malaria. For optimal protective activity, it is thought that antibodies need to have high affinity. A longitudinal study conducted in Uganda followed ...

Iluzanebart’s failure is another ding for a TREM2 space that has already seen a recent high-profile failure. Last November, Alector’s TREM2 antibody failed its own Phase II study for Alzheimer’s ...

Despite significant advancements in salient object detection (SOD) in optical remote sensing images (ORSIs), challenges persist due to the intricate edge structures of ORSIs and the complexity of ...