News

C&EN2d
The Interplay of Antigen Affinity, Internalization, and Pharmacokinetics on CD44-Positive Tumor Targeting of Monoclonal Antibodies | Molecular Pharmaceutics - ACS Publications
Monoclonal antibodies (mAbs) offer promise as effective tumor targeting and drug delivery agents for cancer therapy. However, comparative biological and clinical characteristics of mAbs targeting the ...
C&EN6d
Antibody Fucosylation Lowers the FcγRIIIa/CD16a Affinity by Limiting the Conformations Sampled by the N162-Glycan
Therapeutic monoclonal antibodies (mAbs) are largely based on the immunoglobulin G1 (IgG1) scaffold, and many elicit a cytotoxic cell-mediated response by binding Fc γ receptors. Core fucosylation, a ...
PharmiWeb16d
Aptevo Expands Differentiated CD3 Portfolio with APVO455, Advancing a Suite of Targeted T-cell Engag - PharmiWeb.com
Mipletamig-driven clinical validation of the CRIS-7 derived CD3-binding domain underpins Aptevo's expansion from hematologic to solid tumors New candidate APVO455 targets Nectin-4+ cancers, joins ...
Frontiers18d
Development of high affinity antibodies to Plasmodium falciparum merozoite and sporozoite antigens during infancy and adulthood - Frontiers
Antibodies are important for protection against malaria. For optimal protective activity, it is thought that antibodies need to have high affinity. A longitudinal study conducted in Uganda followed ...
GitHub20d
PRODIGY / Binding Affinity Prediction - GitHub
$ prodigy -h usage: prodigy [-h] [--distance-cutoff DISTANCE_CUTOFF] [--acc-threshold ACC_THRESHOLD] [--temperature TEMPERATURE] [--contact_list] [--pymol_selection] [-q] [--selection A B [A,B C ...]] ...
gut.bmj21d
Anti-CD3 antibody visilizumab is not effective in patients with intravenous corticosteroid-refractory ulcerative colitis - Gut
Background and aims Pilot studies with visilizumab, a humanised monoclonal antibody to CD3, suggest efficacy for corticosteroid-refractory ulcerative colitis (UC). A placebo-controlled trial was ...
Pharm Exec25d
The Antibody-Drug Conjugate Renaissance
We are at an inflection point that is driving a renaissance in antibody-drug conjugate (ADC) development. As successes in the clinic have led to more U.S. Food & Drug Administration (FDA) approvals, ...
CNN26d
Newly approved antibody could offer another option for protecting infants from RSV, a common infection that can be deadly - CNN
The United States could soon have another tool in the fight against respiratory syncytial virus, an illness that’s the No. 1 cause of hospitalization in infants.
Pharm Exec26d
Johnson & Johnson’s First-in-Class Trispecific Antibody Shows High Response Rates in Relapsed or Refractory Multiple Myeloma
Breakthrough Trispecific Antibody Shows Strong Early Efficacy: JNJ-5322 demonstrated an 86.1% overall response rate (ORR) at the recommended Phase II dose in heavily pretreated multiple myeloma ...
PNAS29d
Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens | PNAS
Germline antibodies, and some affinity-matured antibodies, adopt alternative conformations enabling binding of different antigens (12 – 16). This may increase the probability of initiating antibody ...
WAVY-TV29d
Migratory birds develop antibodies to bird flu, officials say
Migratory birds develop antibodies to bird flu, officials say by: Karina F. Garcia Posted: Jun 6, 2025 / 06:33 PM EDT Updated: Jun 6, 2025 / 06:34 PM EDT ...