Efficacy and Tolerability of Meloxicam, a COX-2 Preferential Nonsteroidal Anti-Inflammatory Drug M. Del Tacca, R. Colucci, M. Fornai, C. Blandizzi Disclosures Clin Drug Invest. 2002;22 (12) 0 ...

Introduction: Therapeutic strategies to treat chronic pancreatitis (CP) are very limited. Other chronic inflammatory diseases can be successfully suppressed by selective cyclooxygenase 2 (COX-2) ...

Given the crucial role of synovial macrophages in OA, the mechanism by which Imrecoxib protects joint cartilage and treats OA through the regulation of macrophage polarization deserves further ...

eLife Assessment This study presents important findings on the role of pyramidal cells driving vasoconstriction in brain arteries through a COX-2/PGE2 pathway, with additional contributions from NPY ...

News Release 9-Apr-2025 Machine learning approach to investigating macrophage polarization on various titanium surface characteristics Peer-Reviewed Publication BMEF (BME Frontiers) image: ...

This study unveiled the role of Lrrk2 gene in regulating macrophage polarization and immune response. This finding provides significant insights into the role of Lrrk2 in M1 macrophage modulation ...

COX-2 inhibitors, also known as selective COX-2 inhibitors, are nonsteroidal anti-inflammatory drugs (NSAIDs) that treat inflammatory pain. They’re available by prescription and may be easier on ...

Following polarization of M2 macrophages and siRNA transfection, GL261 mouse glioma cells were seeded into the lower chamber at a density of 1×10 6 cells per well. The coculture of M2 macrophages and ...

After labeling their fastest-binding compounds with carbon-11, the researchers tested the molecules in rats injected with a virus engineered to express COX-2. They found that the strongest signal ...

The specific factors involved in COX‐2 activation depend on both the cell type and the stimulus. Thus, NF‐κB contributes to COX‐2 induction in some, but not all, cell types. Although LPS engages NF‐κB ...